Publications 2008-2009


Developmental Effects of Environment on Reproduction

Adamsson A, Simanainen U, Viluksela M, Paranko J, Toppari J.

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on foetal male rat steroidogenesis.

Int J Androl. 2008 Jul 9. PMID: 18637154


Adamsson A, Salonen V, Paranko J, Toppari J.

Effects of maternal exposure to di-isononylphthalate (DINP) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) on steroidogenesis in the fetal rat testis and adrenal gland.

Reprod Toxicol. 2009 Jul;28(1):66-74. Epub 2009 Mar 20. PMID: 19490997


Aksglaede L, Sørensen K, Petersen JH, Skakkebaek NE, Juul A.

Recent decline inage at breast development: the Copenhagen Puberty Study.

Pediatrics. 2009 May;123(5):e932-9. PubMed PMID: 19403485.


Aksglaede L, Juul A, Olsen LW, Sørensen TI.

Age at puberty and the emerging obesity epidemic.

PLoS One. 2009 Dec 24;4(12):e8450. PubMed PMID: 20041184


Balasch J, Fábregues F, Carmona F, Casamitjana R, Tena-Sempere M.

Ovarian LH priming preceding FSH stimulation: clinical and edocrine effects in women with long-term

hypogonadotropic hypogonadism.

J Clin Endocrinol Metab. 2009 Jul;94(7):2367-73. PubMed PMID:19366842


Boas M, Main KM, Feldt-Rasmussen U.

Environmental chemicals and thyroid function: an update.

Curr Opin Endocrinol Diabetes Obes. 2009 Oct;16(5):385-91. PubMed PMID: 19625957


Brokken LJ, Adamsson A, Paranko J, Toppari J.

Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in

the developing fetal rat testis.

Endocrinology. 2009 Jan;150(1):445-51. PMID: 18772241


Caminos JE, Nogueiras R, Gaytán F, Pineda R, González CR, Barreiro ML, Castaño JP, Malagón MM,

Pinilla L, Toppari J, Diéguez C, Tena-Sempere M.

Novel expression and direct effects of adiponectin in the rat testis.

Endocrinology. 2008 Jul;149(7):3390-402. PubMed PMID: 18403483


Castaño JP, Martínez-Fuentes AJ, Gutiérrez-Pascual E, Vaudry H, Tena-Sempere M, Malagón MM.

Intracellular signaling pathways activated by kisspeptins through GPR54: do multiple signals underlie function diversity?

Peptides. 2009 Jan;30(1):10-5. Review. PubMed PMID: 18775460


Castellano JM, Roa J, Luque RM, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M.

KiSS-1/kisspeptins and the metabolic control of reproduction: physiologic roles and putative physiopathological implications.

Peptides. 2009 Jan;30(1):139-45. Epub 2008 Jun 21. Review. PMID: 18634841


Castellano JM, Navarro VM, Roa J, Pineda R, Sánchez-Garrido MA, García-Galiano D, Vigo E, Dieguez C, Aguilar E,

Pinilla L, Tena-Sempere M.

Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences.

Endocrinology. 2009 Feb;150(2):784-94. PubMed PMID: 18845637


Chauvigné F, Menuet A, Lesné L, Chagnon MC, Chevrier C, Regnier JF, Angerer J, Jégou B.

Time- and dose-related effects of di-(2-ethylhexyl) phthalate and its main metabolites on the function of the rat

fetal testis in vitro.

Environ Health Perspect. 2009 Apr;117(4):515-21. Epub 2008 Dec 1. PMID: 19440488


Damgaard IN, Jensen TK; Nordic Cryptorchidism Study Group, Petersen JH, Skakkebaek NE, Toppari J, Main KM.

Risk factors for congenital cryptorchidism in a prospective birth cohort study.

PLoS ONE. 2008 Aug 25;3(8):e3051. PubMed PMID: 18725961; PubMed Central PMCID: PMC2516600.


Drake AJ, van den Driesche S, Scott HM, Hutchison GR, Seckl JR, Sharpe RM.

Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development.

Endocrinology. 2009 Nov;150(11):5055-64. Epub 2009 Oct 9. PMID: 19819957


Felip A, Zanuy S, Pineda R, Pinilla L, Carrillo M, Tena-Sempere M, Gómez A.

Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different

gonadotropin-releasing activities in fish and mammals.

Mol Cell Endocrinol. 2009 Nov 27;312(1-2):61-71. PubMed PMID: 19084576


Frederiksen H, Taxvig C, Hass U, Vinggaard AM, Nellemann C.

Higher levels of ethyl paraben and butyl paraben in rat amniotic fluid than in maternal plasma after subcutaneous administration.

Toxicol Sci. 2008 Dec;106(2):376-83. PubMed PMID: 18713765


Gaytán F, Gaytán M, Castellano JM, Romero M, Roa J, Aparicio B, Garrido N, Sánchez-Criado JE, Millar RP, Pellicer A,

Fraser HM, Tena-Sempere M.

KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels

in a rat model of ovulatory dysfunction.

Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E520-31.


Gutierrez-Pascual E, Leprince J, Martinez-Fuentes AJ, Segalas-Milazzo I, Pineda R, Roa J, Duran-Prado M,

Guilhaudis L, Desperrois E, Lebreton A, Pinilla L, Tonon MC, Malagon MM, Vaudry H, Tena-Sempere M, Castano J.

In vivo and in vitro structure-activity relationships and structural conformation of kisspeptin-10-related peptides.

Mol Pharmacol. 2009 Jul;76(1):58-67 PubMed PMID: 19389922


Hurme T, Lahdes-Vasama T, Makela E, Iber T, Toppari J.

Clinical findings in prepubertal girls with inguinal hernia with special reference to the diagnosis of androgen insensitivity syndrome.

Scand J Urol Nephrol. 2009;43(1):42-6. PMID: 18752152


Heikkilä J, Taskinen S, Toppari J, Rintala R.

Posterior urethral valves are often associated with cryptorchidism and inguinal hernias.

J Urol. 2008 Aug;180(2):715-7. Epub 2008 Jun 13. PMID: 18554641


Janjua NR, Frederiksen H, Skakkebaek NE, Wulf HC, Andersson AM.

Urinary excretion of phthalates and paraben after repeated whole-body topical application in humans.

Int J Androl. 2008 Apr;31(2):118-30. PubMed PMID: 18194284


Joensen UN, Bossi R, Leffers H, Jensen AA, Skakkebaek NE, Jørgensen N.

Do perfluoroalkyl compounds impair human semen quality?

Environ Health Perspect. 2009 Jun;117(6):923-7. Epub 2009 Mar 2. PubMed PMID: 19590684


Juul A, Sørensen K, Aksglaede L, Garn I, Rajpert-De Meyts E, Hullstein I, Hemmersbach P, Ottesen AM.

A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys.

J Clin Endocrinol Metab. 2009 Mar;94(3):1005-11. PubMed PMID: 19088161


Krysiak-Baltyn K, Toppari J, Skakkebaek NE, Jensen TS, Virtanen HE, Schramm KW, Shen H, Vartiainen T,

Kiviranta H, Taboureau O, Brunak S, Main KM.

Country-specific chemical signatures of persistent environmental compounds in breast milk.

Int J Androl. 2009 Sep 24. [Epub ahead of print] PubMed PMID:19780864.


Lohi S, Lohi O, Vierula M, Maki M, Toppari J.

Coeliac disease autoantibodies in seminal plasma from cases with screen-detected coeliac disease.

Scand J Gastroenterol. 2009;44(4):509-11. PMID: 19031265


Main KM, Skakkebaek NE, Toppari J.

Cryptorchidism as part of the testicular dysgenesis syndrome: the environmental connection.

Endocr Dev. 2009;14:167-73. Epub 2009 Feb 27. PubMed PMID: 19293583


Main KM, Skakkebaek NE, Toppari J.

Re: The true incidence of cryptorchidism in Denmark: D. Cortes, E. M. Kjellberg, M. Breddam

and J. Thorup, J Urol 2008; 179: 314-318.

J Urol. 2009 Feb;181(2):922-4. Epub 2008 Dec 24. PubMed PMID: 19110272.


Mikkelsen JD, Bentsen AH, Ansel L, Simonneaux V, Juul A.

Comparison of the effects of peripherally administered kisspeptins.

Regul Pept. 2009 Jan 8;152(1-3):95-100. PubMed PMID: 18940206


Navarro VM, Sánchez-Garrido MA, Castellano JM, Roa J, García-Galiano D, Pineda R, Aguilar E, Pinilla L,

Tena-Sempere M.

Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical

periods of brain sex differentiation.

Endocrinology. 2009 May;150(5):2359-67.


Navarro VM, Tena-Sempere M.

The KiSS-1/GPR54 system: putative target for endocrine disruption of reproduction at hypothalamic-pituitary unit?

Int J Androl. 2008 Apr;31(2):224-32. PubMed PMID: 17971159


Nurmio M, Tena-Sempere M, Toppari J.

Orexins and the regulation of the hypothalamic-pituitary-testicular axis.

Acta Physiol (Oxf). 2009 May 20. [Epub ahead of print] PMID: 19476455


Pinilla L, Castellano JM, Romero M, Tena-Sempere M, Gaytán F, Aguilar E.

Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the

hypothalamic KiSS-1/ GPR54/GnRH system.

Endocrinology. 2009 Jun;150(6):2889-97. PubMed PMID: 19228890


Roa J, Castellano JM, Navarro VM, Handelsman DJ, Pinilla L, Tena-Sempere M.

Kisspeptins and the control of gonadotropin secretion in male and female rodents.

Peptides. 2009 Jan;30(1):57-66.


Roa J, Vigo E, Castellano JM, Gaytan F, García-Galiano D, Navarro VM, Aguilar E, Dijcks FA, Ederveen AG,

Pinilla L, van Noort PI, Tena-Sempere M.

Follicle-stimulating hormone responses to kisspeptin in the female rat at the preovulatory period: modulation by

estrogen and progesterone receptors.

Endocrinology. 2008 Nov;149(11):5783-90.


Roa J, Garcia-Galiano D, Varela L, Sánchez-Garrido MA, Pineda R, Castellano JM, Ruiz-Pino F, Romero M, Aguilar E,

López M, Gaytan F, Diéguez C, Pinilla L, Tena-Sempere M.

The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system.

Endocrinology. 2009 Nov;150(11):5016-26. Epub 2009 Sep 4. PMID: 19734277


Roa J, Vigo E, García-Galiano D, Castellano JM, Navarro VM, Pineda R, Diéguez C, Aguilar E, Pinilla L, Tena-Sempere M.

Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states.

Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1088-96. PubMed PMID: 18413669


Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML,

Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP.

Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation.

J Neurosci. 2009 Mar 25;29(12):3920-9.PubMed PMID: 19321788


Scott HM, Hutchison GR, Jobling MS, McKinnell C, Drake AJ, Sharpe RM.

Relationship between androgen action in the "male programming window," fetal sertoli cell number, and adult testis size in the rat.

Endocrinology. 2008 Oct;149(10):5280-7. PubMed PMID: 18566125


Scott HM, Mason JI, Sharpe RM.

Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds.

Endocr Rev. 2009 Dec;30(7):883-925. PubMed PMID: 19887492


Sirotkin AV, Chrenková M, Nitrayová S, Patras P, Darlak K, Valenzuela F, Pinilla L, Tena-Sempere M.

Effects of chronic food restriction and treatments with leptin or ghrelin on different reproductive parameters of male rats.

Peptides. 2008 Aug;29(8):1362-8. PubMed PMID: 18455268


Sørensen K, Aksglaede L, Munch-Andersen T, Aachmann-Andersen NJ, Petersen JH, Hilsted L, Helge JW, Juul A.

Sex hormone-binding globulin levels predict insulin sensitivity, disposition index, and cardiovascular risk during puberty.

Diabetes Care. 2009 May;32(5):909-14. PubMed PMID: 19196890


Sørensen K, Aksglaede L, Munch-Andersen T, Aachmann-Andersen NJ, Leffers H, Helge JW, Hilsted L, Juul A.

Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty.

J Clin Endocrinol Metab. 2009 Aug;94(8):2966-9. PubMed PMID: 19417039


Taxvig C, Vinggaard AM, Hass U, Axelstad M, Boberg J, Hansen PR, Frederiksen H, Nellemann C.

Do parabens have the ability to interfere with steroidogenesis?

Toxicol Sci. 2008 Nov;106(1):206-13. PubMed PMID: 18648085


Tena-Sempere M.

Timeline: the role of kisspeptins in reproductive biology.

Nat Med. 2008 Nov;14(11):1196. PubMed PMID: 18989306


Tena-Sempere M.

Ghrelin as a pleotrophic modulator of gonadal function and reproduction.

Nat Clin Pract Endocrinol Metab. 2008 Dec;4(12):666-74. PubMed PMID: 18981992


Tena-Sempere M, Vaudry H.


Peptides. 2009 Jan;30(1):1-3. PubMed PMID: 18771699


Tena-Sempere M.

Kisspeptin signaling in the brain: Recent developments and future challenges.

Mol Cell Endocrinol. 2009 May 21. [Epub ahead of print] PMID: 19464345


Toppari J.

Environmental endocrine disrupters.

Sex Dev. 2008;2(4-5):260-7. PubMed PMID: 18987500


Wohlfahrt-Veje C, Main KM, Skakkebæk NE.

Testicular Dysgenesis Syndrome; Fetal origin of adult reproductive problems.

Clin Endocrinol (Oxf). 2009 Oct;71(4):459-65. PubMed PMID: 19222487


Wohlfahrt-Veje C, Boisen KA, Boas M, Damgaard IN, Kai CM, Schmidt IM, Chellakooty M, Suomi AM, Toppari J,

Skakkebaek NE, Main KM.

Acquired cryptorchidism is frequent in infancy and childhood.

Int J Androl. 2009 Aug;32(4):423-8. PMID: 19515170