Publications 2008-2009

DEER

Developmental Effects of Environment on Reproduction

Adamsson A, Simanainen U, Viluksela M, Paranko J, Toppari J.

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on foetal male rat steroidogenesis.

Int J Androl. 2008 Jul 9. PMID: 18637154

Adamsson A, Salonen V, Paranko J, Toppari J.

Effects of maternal exposure to di-isononylphthalate (DINP) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) on steroidogenesis in the fetal rat testis and adrenal gland.

Reprod Toxicol. 2009 Jul;28(1):66-74. Epub 2009 Mar 20. PMID: 19490997

Aksglaede L, Sørensen K, Petersen JH, Skakkebaek NE, Juul A.

Recent decline inage at breast development: the Copenhagen Puberty Study.

Pediatrics. 2009 May;123(5):e932-9. PubMed PMID: 19403485.

Aksglaede L, Juul A, Olsen LW, Sørensen TI.

Age at puberty and the emerging obesity epidemic.

PLoS One. 2009 Dec 24;4(12):e8450. PubMed PMID: 20041184

Balasch J, Fábregues F, Carmona F, Casamitjana R, Tena-Sempere M.

Ovarian LH priming preceding FSH stimulation: clinical and edocrine effects in women with long-term

hypogonadotropic hypogonadism.

J Clin Endocrinol Metab. 2009 Jul;94(7):2367-73. PubMed PMID:19366842

Boas M, Main KM, Feldt-Rasmussen U.

Environmental chemicals and thyroid function: an update.

Curr Opin Endocrinol Diabetes Obes. 2009 Oct;16(5):385-91. PubMed PMID: 19625957

Brokken LJ, Adamsson A, Paranko J, Toppari J.

Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in

the developing fetal rat testis.

Endocrinology. 2009 Jan;150(1):445-51. PMID: 18772241

Caminos JE, Nogueiras R, Gaytán F, Pineda R, González CR, Barreiro ML, Castaño JP, Malagón MM,

Pinilla L, Toppari J, Diéguez C, Tena-Sempere M.

Novel expression and direct effects of adiponectin in the rat testis.

Endocrinology. 2008 Jul;149(7):3390-402. PubMed PMID: 18403483

Castaño JP, Martínez-Fuentes AJ, Gutiérrez-Pascual E, Vaudry H, Tena-Sempere M, Malagón MM.

Intracellular signaling pathways activated by kisspeptins through GPR54: do multiple signals underlie function diversity?

Peptides. 2009 Jan;30(1):10-5. Review. PubMed PMID: 18775460

Castellano JM, Roa J, Luque RM, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M.

KiSS-1/kisspeptins and the metabolic control of reproduction: physiologic roles and putative physiopathological implications.

Peptides. 2009 Jan;30(1):139-45. Epub 2008 Jun 21. Review. PMID: 18634841

Castellano JM, Navarro VM, Roa J, Pineda R, Sánchez-Garrido MA, García-Galiano D, Vigo E, Dieguez C, Aguilar E,

Pinilla L, Tena-Sempere M.

Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences.

Endocrinology. 2009 Feb;150(2):784-94. PubMed PMID: 18845637

Chauvigné F, Menuet A, Lesné L, Chagnon MC, Chevrier C, Regnier JF, Angerer J, Jégou B.

Time- and dose-related effects of di-(2-ethylhexyl) phthalate and its main metabolites on the function of the rat

fetal testis in vitro.

Environ Health Perspect. 2009 Apr;117(4):515-21. Epub 2008 Dec 1. PMID: 19440488

Damgaard IN, Jensen TK; Nordic Cryptorchidism Study Group, Petersen JH, Skakkebaek NE, Toppari J, Main KM.

Risk factors for congenital cryptorchidism in a prospective birth cohort study.

PLoS ONE. 2008 Aug 25;3(8):e3051. PubMed PMID: 18725961; PubMed Central PMCID: PMC2516600.

Drake AJ, van den Driesche S, Scott HM, Hutchison GR, Seckl JR, Sharpe RM.

Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development.

Endocrinology. 2009 Nov;150(11):5055-64. Epub 2009 Oct 9. PMID: 19819957

Felip A, Zanuy S, Pineda R, Pinilla L, Carrillo M, Tena-Sempere M, Gómez A.

Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different

gonadotropin-releasing activities in fish and mammals.

Mol Cell Endocrinol. 2009 Nov 27;312(1-2):61-71. PubMed PMID: 19084576

Frederiksen H, Taxvig C, Hass U, Vinggaard AM, Nellemann C.

Higher levels of ethyl paraben and butyl paraben in rat amniotic fluid than in maternal plasma after subcutaneous administration.

Toxicol Sci. 2008 Dec;106(2):376-83. PubMed PMID: 18713765

Gaytán F, Gaytán M, Castellano JM, Romero M, Roa J, Aparicio B, Garrido N, Sánchez-Criado JE, Millar RP, Pellicer A,

Fraser HM, Tena-Sempere M.

KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels

in a rat model of ovulatory dysfunction.

Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E520-31.

Gutierrez-Pascual E, Leprince J, Martinez-Fuentes AJ, Segalas-Milazzo I, Pineda R, Roa J, Duran-Prado M,

Guilhaudis L, Desperrois E, Lebreton A, Pinilla L, Tonon MC, Malagon MM, Vaudry H, Tena-Sempere M, Castano J.

In vivo and in vitro structure-activity relationships and structural conformation of kisspeptin-10-related peptides.

Mol Pharmacol. 2009 Jul;76(1):58-67 PubMed PMID: 19389922

Hurme T, Lahdes-Vasama T, Makela E, Iber T, Toppari J.

Clinical findings in prepubertal girls with inguinal hernia with special reference to the diagnosis of androgen insensitivity syndrome.

Scand J Urol Nephrol. 2009;43(1):42-6. PMID: 18752152

Heikkilä J, Taskinen S, Toppari J, Rintala R.

Posterior urethral valves are often associated with cryptorchidism and inguinal hernias.

J Urol. 2008 Aug;180(2):715-7. Epub 2008 Jun 13. PMID: 18554641

Janjua NR, Frederiksen H, Skakkebaek NE, Wulf HC, Andersson AM.

Urinary excretion of phthalates and paraben after repeated whole-body topical application in humans.

Int J Androl. 2008 Apr;31(2):118-30. PubMed PMID: 18194284

Joensen UN, Bossi R, Leffers H, Jensen AA, Skakkebaek NE, Jørgensen N.

Do perfluoroalkyl compounds impair human semen quality?

Environ Health Perspect. 2009 Jun;117(6):923-7. Epub 2009 Mar 2. PubMed PMID: 19590684

Juul A, Sørensen K, Aksglaede L, Garn I, Rajpert-De Meyts E, Hullstein I, Hemmersbach P, Ottesen AM.

A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys.

J Clin Endocrinol Metab. 2009 Mar;94(3):1005-11. PubMed PMID: 19088161

Krysiak-Baltyn K, Toppari J, Skakkebaek NE, Jensen TS, Virtanen HE, Schramm KW, Shen H, Vartiainen T,

Kiviranta H, Taboureau O, Brunak S, Main KM.

Country-specific chemical signatures of persistent environmental compounds in breast milk.

Int J Androl. 2009 Sep 24. [Epub ahead of print] PubMed PMID:19780864.

Lohi S, Lohi O, Vierula M, Maki M, Toppari J.

Coeliac disease autoantibodies in seminal plasma from cases with screen-detected coeliac disease.

Scand J Gastroenterol. 2009;44(4):509-11. PMID: 19031265

Main KM, Skakkebaek NE, Toppari J.

Cryptorchidism as part of the testicular dysgenesis syndrome: the environmental connection.

Endocr Dev. 2009;14:167-73. Epub 2009 Feb 27. PubMed PMID: 19293583

Main KM, Skakkebaek NE, Toppari J.

Re: The true incidence of cryptorchidism in Denmark: D. Cortes, E. M. Kjellberg, M. Breddam

and J. Thorup, J Urol 2008; 179: 314-318.

J Urol. 2009 Feb;181(2):922-4. Epub 2008 Dec 24. PubMed PMID: 19110272.

Mikkelsen JD, Bentsen AH, Ansel L, Simonneaux V, Juul A.

Comparison of the effects of peripherally administered kisspeptins.

Regul Pept. 2009 Jan 8;152(1-3):95-100. PubMed PMID: 18940206

Navarro VM, Sánchez-Garrido MA, Castellano JM, Roa J, García-Galiano D, Pineda R, Aguilar E, Pinilla L,

Tena-Sempere M.

Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical

periods of brain sex differentiation.

Endocrinology. 2009 May;150(5):2359-67.

Navarro VM, Tena-Sempere M.

The KiSS-1/GPR54 system: putative target for endocrine disruption of reproduction at hypothalamic-pituitary unit?

Int J Androl. 2008 Apr;31(2):224-32. PubMed PMID: 17971159

Nurmio M, Tena-Sempere M, Toppari J.

Orexins and the regulation of the hypothalamic-pituitary-testicular axis.

Acta Physiol (Oxf). 2009 May 20. [Epub ahead of print] PMID: 19476455

Pinilla L, Castellano JM, Romero M, Tena-Sempere M, Gaytán F, Aguilar E.

Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the

hypothalamic KiSS-1/ GPR54/GnRH system.

Endocrinology. 2009 Jun;150(6):2889-97. PubMed PMID: 19228890

Roa J, Castellano JM, Navarro VM, Handelsman DJ, Pinilla L, Tena-Sempere M.

Kisspeptins and the control of gonadotropin secretion in male and female rodents.

Peptides. 2009 Jan;30(1):57-66.

Roa J, Vigo E, Castellano JM, Gaytan F, García-Galiano D, Navarro VM, Aguilar E, Dijcks FA, Ederveen AG,

Pinilla L, van Noort PI, Tena-Sempere M.

Follicle-stimulating hormone responses to kisspeptin in the female rat at the preovulatory period: modulation by

estrogen and progesterone receptors.

Endocrinology. 2008 Nov;149(11):5783-90.

Roa J, Garcia-Galiano D, Varela L, Sánchez-Garrido MA, Pineda R, Castellano JM, Ruiz-Pino F, Romero M, Aguilar E,

López M, Gaytan F, Diéguez C, Pinilla L, Tena-Sempere M.

The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system.

Endocrinology. 2009 Nov;150(11):5016-26. Epub 2009 Sep 4. PMID: 19734277

Roa J, Vigo E, García-Galiano D, Castellano JM, Navarro VM, Pineda R, Diéguez C, Aguilar E, Pinilla L, Tena-Sempere M.

Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states.

Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1088-96. PubMed PMID: 18413669

Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML,

Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP.

Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation.

J Neurosci. 2009 Mar 25;29(12):3920-9.PubMed PMID: 19321788

Scott HM, Hutchison GR, Jobling MS, McKinnell C, Drake AJ, Sharpe RM.

Relationship between androgen action in the "male programming window," fetal sertoli cell number, and adult testis size in the rat.

Endocrinology. 2008 Oct;149(10):5280-7. PubMed PMID: 18566125

Scott HM, Mason JI, Sharpe RM.

Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds.

Endocr Rev. 2009 Dec;30(7):883-925. PubMed PMID: 19887492

Sirotkin AV, Chrenková M, Nitrayová S, Patras P, Darlak K, Valenzuela F, Pinilla L, Tena-Sempere M.

Effects of chronic food restriction and treatments with leptin or ghrelin on different reproductive parameters of male rats.

Peptides. 2008 Aug;29(8):1362-8. PubMed PMID: 18455268

Sørensen K, Aksglaede L, Munch-Andersen T, Aachmann-Andersen NJ, Petersen JH, Hilsted L, Helge JW, Juul A.

Sex hormone-binding globulin levels predict insulin sensitivity, disposition index, and cardiovascular risk during puberty.

Diabetes Care. 2009 May;32(5):909-14. PubMed PMID: 19196890

Sørensen K, Aksglaede L, Munch-Andersen T, Aachmann-Andersen NJ, Leffers H, Helge JW, Hilsted L, Juul A.

Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty.

J Clin Endocrinol Metab. 2009 Aug;94(8):2966-9. PubMed PMID: 19417039

Taxvig C, Vinggaard AM, Hass U, Axelstad M, Boberg J, Hansen PR, Frederiksen H, Nellemann C.