Publications 2010-2011

DEER

Developmental Effects of Environment on Reproduction

Asklund C, Jensen TK, Main KM, Sobotka T, Skakkebæk NE, Jørgensen N.

Semen quality, reproductive hormones and fertility of men operated for hypospadias.

Int J Androl. 2010 Feb;33(1):80-7. PubMed PMID: 19281491

 

Auharek SA, de Franca LR, McKinnell C, Jobling MS, Scott HM, Sharpe RM.

Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat.

Endocrinology. 2010 Jun;151(6):2868-75. PubMed PMID: 20392824

 

Bay K, Main KM, Toppari J, Skakkebæk NE; Medscape.

Testicular descent: INSL3, testosterone, genes and the intrauterine milieu.

Nat Rev Urol. 2011 Apr;8(4):187-96. PubMed PMID: 21403659

 

Bentsen AH, Ansel L, Simonneaux V, Tena-Sempere M, Juul A, Mikkelsen JD.

Maturation of kisspeptinergic neurons coincides with puberty onset in male rats.

Peptides. 2010 Feb;31(2):275-83. PubMed PMID: 19944729

 

Castellano JM, Bentsen AH, Mikkelsen JD, Tena-Sempere M.

Kisspeptins: bridging energy homeostasis and reproduction.

Brain Res. 2010 Dec 10;1364:129-38. PubMed PMID: 20800054

 

Castellano JM, Bentsen AH, Romero M, Pineda R, Ruiz-Pino F, Garcia-Galiano D, Sánchez-Garrido MA, Pinilla L, Mikkelsen JD, Tena-Sempere M.

Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects.

Am J Physiol Endocrinol Metab. 2010 Jul;299(1):E54-61. PubMed PMID: 20407007

 

Courant F, Aksglaede L, Antignac JP, Monteau F, Sorensen K, Andersson AM, Skakkebaek NE, Juul A, Le Bizec B.

Assessment of Circulating Sex Steroid Levels in Prepubertal and Pubertal Boys and Girls by a Novel

Ultrasensitive Gas Chromatography-Tandem Mass Spectrometry Method.

J Clin Endocrinol Metab. 2010 Jan;95(1):82-92. PubMed PMID: 19933393

 

García-Galiano D, Navarro VM, Roa J, Ruiz-Pino F, Sánchez-Garrido MA, Pineda R, Castellano JM, Romero M, Aguilar E, Gaytán F, Diéguez C, Pinilla L, Tena-Sempere M.

The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat.

J Neurosci. 2010 Jun 9;30(23):7783-92. PubMed PMID: 20534827

 

Jobling MS, Hutchison GR, van den Driesche S, Sharpe RM.

Effects of di(n-butyl) phthalate exposure on fetal rat germ cell number and differentiation: identification of age-specific windows of vulnerability.

Int J Androl. 2011, Oct;34(5 Pt 2):e386-96. Epub 2011 Feb 18.PMID:21332505

 

Jørgensen N, Vierula M, Jacobsen R, Pukkala E, Perheentupa A, Virtanen HE, Skakkebaek NE, Toppari J.

Recent adverse trends in semen quality and testis cancer incidence among Finnish men.

Int J Androl. 2011 Mar 2. [Epub ahead of print] PubMed PMID: 21366607

 

Kristensen DM, Hass U, Lesné L, Lottrup G, Jacobsen PR, Desdoits-Lethimonier C, Boberg J, Petersen JH, Toppari J, Jensen TK, Brunak S, Skakkebaek NE, Nellemann C, Main KM, Jégou B, Leffers H.

Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat.

Hum Reprod. 2011 Jan;26(1):235-44. PubMed PMID: 21059752

 

López M, Tena-Sempere M, Diéguez C.

Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes).

Front Neuroendocrinol. 2010 Apr;31(2):113-27. PubMed PMID: 19654017

 

Luque RM, Córdoba-Chacón J, Gahete MD, Navarro VM, Tena-Sempere M, Kineman RD, Castaño JP.

Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms.

Endocrinology. 2011 Mar;152(3):957-66. PubMed PMID: 21209013

 

MacLeod DJ, Sharpe RM, Welsh M, Fisken M, Scott HM, Hutchison GR, Drake AJ, van den Driesche S.

Androgen action in the masculinization programming window and development of male reproductive organs

Int J Androl. 2010 Apr;33(2):279-87. PubMed PMID: 20002220

 

Main KM, Skakkebaek NE, Virtanen HE, Toppari J.

Genital anomalies in boys and the environment.

Best Pract Res Clin Endocrinol Metab. 2010 Apr;24(2):279-89. PubMed PMID: 20541152

 

Mogensen SS, Aksglaede L, Mouritsen A, Sørensen K, Main KM, Gideon P, Juul A.

Diagnostic Work-Up of 449 Consecutive Girls Who Were Referred to be Evaluated for Precocious Puberty.

J Clin Endocrinol Metab. 2011 May;96(5):1393-401. PubMed PMID: 21346077

 

Mouritsen A, Aksglaede L, Sørensen K, Mogensen SS, Leffers H, Main KM, Frederiksen H, Andersson AM,

Skakkebaek NE, Juul A.

Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty.

Int J Androl. 2010 Apr;33(2):346-59. PubMed PMID: 20487042

 

Navarro VM, Castellano JM, McConkey SM, Pineda R, Ruiz-Pino F, Pinilla L, Clifton DK, Tena-Sempere M, Steiner RA.

Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat.

Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E202-10. PubMed PMID: 21045176

 

Navarro VM, Tena-Sempere M.

Kisspeptins and the neuroendocrine control of reproduction.

Front Biosci (Schol Ed). 2011 Jan 1;3:267-75. PubMed PMID: 21196375

 

Olea N, Sharpe R, Jegou B, Toppari J, Skakkebaek NE, Schlatt S, Heindel J.

Male reproductive health.

Science Policy Briefing, European Science Foundation. 2010

 

Pineda R, Garcia-Galiano D, Roseweir A, Romero M, Sanchez-Garrido MA, Ruiz-Pino F, Morgan K, Pinilla L, Millar RP, Tena-Sempere M.

Critical roles of kisspeptins in female puberty and preovulatory gonadotropin surges as revealed by a novel antagonist.

Endocrinology. 2010 Feb;151(2):722-30. PubMed PMID: 19952274

 

Pineda R, Garcia-Galiano D, Sanchez-Garrido MA, Romero M, Ruiz-Pino F, Aguilar E, Dijcks FA, Blomenröhr M, Pinilla L, van Noort PI, Tena-Sempere M.

Characterization of the potent gonadotropin-releasing activity of RF9, a selective antagonist of RF-amide-related peptides and neuropeptide FF receptors: physiological and pharmacological implications.

Endocrinology. 2010 Apr;151(4):1902-13. PubMed PMID: 20160130

 

Pineda R, Aguilar E, Pinilla L, Tena-Sempere M.

Physiological roles of the kisspeptin/GPR54 system in the neuroendocrine control of reproduction.

Prog Brain Res. 2010;181:55-77. PubMed PMID: 20478433

 

Pineda R, Garcia-Galiano D, Sanchez-Garrido MA, Romero M, Ruiz-Pino F, Aguilar E, Dijcks FA, Blomenröhr M, Pinilla L, van Noort PI, Tena-Sempere M.

Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies.

Am J Physiol Endocrinol Metab. 2010 Jul;299(1):E39-46. PubMed PMID: 20424142

 

Pinilla L, Pineda R, Gaytán F, Romero M, García-Galiano D, Sánchez-Garrido MA, Ruiz-Pino F, Tena-Sempere M, Aguilar E.

Characterization of the reproductive effects of the anorexigenic VGF-derived peptide TLQP-21: in vivo and in vitro studies in male rats.

Am J Physiol Endocrinol Metab. 2011 May;300(5):E837-47. PubMed PMID: 21304062

 

Roa J, García-Galiano D, Castellano JM, Gaytan F, Pinilla L, Tena-Sempere M.

Metabolic control of puberty onset: new players, new mechanisms.

Mol Cell Endocrinol. 2010 Aug 5;324(1-2):87-94. PubMed PMID: 20026241

 

Roa J, Tena-Sempere M.

Energy balance and puberty onset: emerging role of central mTOR signaling.

Trends Endocrinol Metab. 2010 Sep;21(9):519-28. PubMed PMID: 20554449

 

Sharpe RM.

Environmental/lifestyle effects on spermatogenesis.

Philos Trans R Soc Lond B Biol Sci. 2010 May 27;365(1546):1697-712. PubMed PMID: 20403879

 

Sharpe RM.

Development and maturation of the normal male reproductive system.

In: Woodruff TJ, Janssen SJ, Guillette LJ Jr, Giudice LC Eds Environmental impacts on reproductive health and fertility. 2010. Pages 48-59. Cambridge University Press

 

Sharpe RM, Auharek S, Scott HM, Renato de Franca L, Drake AJ, van den Driesche S.

Origin of testicular dysgenesis syndrome disorders in the masculinisation programming window: relevance to final testis size (=sperm production).

Ipsen Foundation publication 2011, In press.

 

Sørensen K, Aksglaede L, Petersen JH, Juul A.

Recent changes in pubertal timing in healthy Danish boys: associations with body mass index.

J Clin Endocrinol Metab. 2010 Jan;95(1):263-70. PubMed PMID: 19926714

 

Sørensen K, Aksglaede L, Petersen JH, Leffers H, Juul A.

The exon 3 deleted growth hormone receptor gene is associated with small birth size and early pubertal onset in healthy boys.

J Clin Endocrinol Metab. 2010 Jun;95(6):2819-26. PubMed PMID: 20382688

 

Taboureau O, Nielsen SK, Audouze K, Weinhold N, Edsgärd D, Roque FS, Kouskoumvekaki I, Bora A, Curpan R, Jensen TS, Brunak S, Oprea TI.

ChemProt: a disease chemical biology database.

Nucleic Acids Res. 2011 Jan;39(Database issue):D367-72. PubMed PMID: 20935044

 

Tena-Sempere M.

Kisspeptin/GPR54 system as potential target for endocrine disruption of reproductive development and function.

Int J Androl. 2010 Apr;33(2):360-8. PubMed PMID: 19906185

 

Tena-Sempere M.

Roles of kisspeptins in the control of hypothalamic-gonadotropic function: focus on sexual differentiation and puberty onset.

Endocr Dev. 2010;17:52-62. PubMed PMID: 19955756

 

Tena-Sempere M.

Neuroendocrinology of puberty: recent milestones and new challenges.

Mol Cell Endocrinol. 2010 Aug 5;324(1-2):1-2. PubMed PMID: 20493922

 

Tena-Sempere M.

Kisspeptins and the metabolic control of reproduction: physiologic roles and physiopathological implications.

Ann Endocrinol (Paris). 2010 May;71(3):201-2. PubMed PMID: 20362974

 

Toppari J, Juul A.

Trends in puberty timing in humans and environmental modifiers.

Mol Cell Endocrinol. 2010 Aug 5;324(1-2):39-44. PubMed PMID: 20298746

 

Toppari J, Virtanen HE, Main KM, Skakkebaek NE.

Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connection.

Birth Defects Res A Clin Mol Teratol. 2010 Oct;88(10):910-9. PubMed PMID: 20865786

 

Trépos-Pouplard M, Lardenois A, Staub C, Guitton N, Dorval-Coiffec I, Pineau C, Primig M, Jégou B.

Proteome analysis and genome-wide regulatory motif prediction identify novel potentially sex-hormone regulated proteins

in rat efferent ducts.

Int J Androl. 2010 Oct 1;33(5):661-74. PubMed PMID: 19906187

 

Frederiksen H, Jørgensen N, Andersson AM.

Correlations between phthalate metabolites in urine, serum, and seminal plasma from young Danish men determined by isotope dilution liquid chromatography tandem mass spectrometry.

J Anal Toxicol. 2010 Sep;34(7):400-10.PMID:20822678

 

Jørgensen N, Liu F, Andersson AM, Vierula M, Irvine DS, Auger J, Brazil CK, Drobnis EZ, Jensen TK, Jouannet P, Overstreet JW, Redmon JB, Sparks A, Toppari J, Wang C, Skakkebæk NE, Swan SH.

Serum inhibin-b in fertile men is strongly correlated with low but not high sperm counts: a coordinated study of 1,797 European and US men.

Fertil Steril. 2010 Nov;94(6):2128-34. Epub 2010 Feb 10.PMID:20149358

 

Nurmio M, Tena-Sempere M, Toppari J.

Orexins and the regulation of the hypothalamic-pituitary-testicular axis.

Acta Physiol (Oxf). 2010 Mar;198(3):349-54. Epub 2009 May 20. Review.PMID:19476455

 

Pineda R, Aguilar E, Pinilla L, Tena-Sempere M.

Physiological roles of the kisspeptin/GPR54 system in the neuroendocrine control of reproduction.

Prog Brain Res. 2010;181:55-77. Review.PMID:20478433

 

Pineda R, Garcia-Galiano D, Sanchez-Garrido MA, Romero M, Ruiz-Pino F, Aguilar E, Dijcks FA, Blomenröhr M, Pinilla L, van Noort PI, Tena-Sempere M.

Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies.

Am J Physiol Endocrinol Metab. 2010 Jul;299(1):E39-46. Epub 2010 Apr 27.

PMID:20424142

 

Welsh M, MacLeod DJ, Walker M, Smith LB, Sharpe RM.

Critical androgen-sensitive periods of rat penis and clitoris development.

Int J Androl. 2010 Feb;33(1):e144-52. Epub 2009 Jul 28. PMID:19656234

Tena-Sempere M.

 

Kisspeptin signaling in the brain: recent developments and future challenges.

Mol Cell Endocrinol. 2010 Jan 27;314(2):164-9. Epub 2009 May 21. Review.PMID:

19464345

 

Blanco Martínez de Morentin P, González CR, Saha AK, Martins L, Diéguez C, Vidal-Puig A, Tena-Sempere M, López M.

Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance.

Rev Endocr Metab Disord. 2011 Sep;12(3):127-40. doi: 10.1007/s11154-011-9165-5. Review. PMID:21347863

 

Castellano JM, Bentsen AH, Sánchez-Garrido MA, Ruiz-Pino F, Romero M, Garcia-Galiano D, Aguilar E, Pinilla L, Diéguez C, Mikkelsen JD, Tena-Sempere M.

Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system.

Endocrinology. 2011 Sep;152(9):3396-408. Epub 2011 Jun 28. PMID:21712362

 

Chauvigné F, Plummer S, Lesné L, Cravedi JP, Dejucq-Rainsford N, Fostier A, Jégou B.

Mono-(2-ethylhexyl) phthalate directly alters the expression of Leydig cell genes and CYP17 lyase activity in cultured rat fetal testis.

PLoS One. 2011;6(11):e27172. Epub 2011 Nov 7. PMID:22087261

 

Fuente-Martín E, Granado M, García-Cáceres C, Sanchez-Garrido MA, Frago LM, Tena-Sempere M, Argente J, Chowen JA.

Early nutritional changes induce sexually dimorphic long-term effects on body weight gain and the response to sucrose intake in adult rats.

Metabolism. 2011 Dec 28. [Epub ahead of print] PMID:22209665

 

Kristensen DM, Skalkam ML, Audouze K, Lesné L, Desdoits-Lethimonier C, Frederiksen H, Brunak S, Skakkebæk NE, Jégou B, Hansen JB, Junker S, Leffers H.

Many putative endocrine disruptors inhibit prostaglandin synthesis.

Environ Health Perspect. 2011 Apr;119(4):534-41. Epub 2010 Nov 16.PMID:21081300

 

Laitinen EM, Tommiska J, Virtanen HE, Oehlandt H, Koivu R, Vaaralahti K, Toppari J, Raivio T.

Isolated cryptorchidism: no evidence for involvement of genes underlying isolated hypogonadotropic hypogonadism.

Mol Cell Endocrinol. 2011 Jul 20;341(1-2):35-8. Epub 2011 Jun 1.PMID:21664240

 

Le Marec O, Neveu C, Lefranc B, Dubessy C, Boutin JA, Do-Régo JC, Costentin J, Tonon MC, Tena-Sempere M, Vaudry H, Leprince J.

Structure-activity relationships of a series of analogues of the RFamide-related peptide 26RFa.

J Med Chem. 2011 Jul 14;54(13):4806-14. Epub 2011 Jun 9.PMID:21623631

 

Mendiola J, Stahlhut RW, Jørgensen N, Liu F, Swan SH.

Shorter anogenital distance predicts poorer semen quality in young men in Rochester, New York.

Environ Health Perspect. 2011 Jul;119(7):958-63. Epub 2011 Mar 1.PMID:21377950

 

Meza-Herrera CA, Hernández-Valenzuela LC, González-Bulnes A, Tena-Sempere M, Abad-Zavaleta J, Salinas-Gonzalez H, Mellado M, Veliz-Deras F.

Long-term betacarotene-supplementation enhances serum insulin concentrations without effect on the onset of puberty in the female goat.

Reprod Biol. 2011 Nov;11(3):236-49.PMID:22139337

 

Navarro VM, Tena-Sempere M.

Kisspeptins and the neuroendocrine control of reproduction.

Front Biosci (Schol Ed). 2011 Jan 1;3:267-75. Review.PMID:21196375

 

Navarro VM, Gottsch ML, Wu M, García-Galiano D, Hobbs SJ, Bosch MA, Pinilla L, Clifton DK, Dearth A, Ronnekleiv OK, Braun RE, Palmiter RD, Tena-Sempere M, Alreja M, Steiner RA.

Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse.

Endocrinology. 2011 Nov;152(11):4265-75. Epub 2011 Sep 13.PMID:21914775

 

Navarro VM, Tena-Sempere M.

Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility.

Nat Rev Endocrinol. 2011 Sep 13;8(1):40-53. doi: 10.1038/nrendo.2011.147.PMID:

21912400

 

Ravnborg TL, Jensen TK, Andersson AM, Toppari J, Skakkebaek NE, Jørgensen N.

Prenatal and adult exposures to smoking are associated with adverse effects on reproductive hormones, semen quality, final height and body mass index.

Hum Reprod. 2011 May;26(5):1000-11. Epub 2011 Feb 18.PMID:21335416

 

Roa J, Navarro VM, Tena-Sempere M.

Kisspeptins in reproductive biology: consensus knowledge and recent developments.

Biol Reprod. 2011 Oct;85(4):650-60. Epub 2011 Jun 15. Review. PMID:21677307

 

Ruscica M, Dozio E, Steffani L, Passafaro L, Mazzer M, Castellano JM, Motta M, Tena-Sempere M, Magni P.

Role of the energy sensor adenosine monophosphate-activated protein kinase in the regulation of immature gonadotropin-releasing hormone neuron migration.

J Endocrinol Invest. 2011 Nov;34(10):e362-8. Epub 2011 Jun 21.PMID:21697647

 

Sharpe RM.

Pediatrics: endocrine disruption and human health effects-a call to action.

Nat Rev Endocrinol. 2011 Sep 20;7(11):633-4. doi: 10.1038/nrendo.2011.165. No abstract available. PMID:21931368

 

Sharpe RM.

Low sperm counts may be preventable.

Science. 2011 Sep 9;333(6048):1380-1. PMID:21903792

 

Tapia-González S, García-Segura LM, Tena-Sempere M, Frago LM, Castellano JM, Fuente-Martín E, García-Cáceres C, Argente J, Chowen JA.

Activation of microglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition.

J Neuroendocrinol. 2011 Apr;23(4):365-70. doi: 10.1111/j.1365-2826.2011.02113.x.

PMID:21314736

 

Tommiska J, Sørensen K, Aksglaede L, Koivu R, Puhakka L, Juul A, Raivio T.

LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty.

BMC Res Notes. 2011 Sep 22;4:363.PMID:21939553

 

van den Driesche S, Scott HM, MacLeod DJ, Fisken M, Walker M, Sharpe RM.

Relative importance of prenatal and postnatal androgen action in determining growth of the penis and anogenital distance in the rat before, during and after puberty.

Int J Androl. 2011 Dec;34(6 Pt 2):e578-86. doi: 10.1111/j.1365-2605.2011.01175.x. Epub 2011 Jun 2.PMID:21631528